Daiichi Sankyo and AstraZeneca Enter New Global Development and Commercialization Collaboration
Daiichi Sankyo Company, Limited announced on July 27, 2020 that it has entered into a global development and commercialization agreement with AstraZeneca for Daiichi Sankyo’s DS-1062, a TROP2 directed DXd antibody drug conjugate (ADC), currently in phase 1 clinical development for non-small cell lung cancer (NSCLC) and triple negative breast cancer (TNBC).
Daiichi Sankyo and AstraZeneca will jointly develop and commercialize DS-1062 worldwide, except in Japan where Daiichi Sankyo will maintain exclusive rights. Daiichi Sankyo will manufacture and supply DS-1062.
This agreement represents the second global ADC collaboration between the two companies following a similar agreement in March 2019 for Daiichi Sankyo’s ENHERTU®, a HER2 directed DXd ADC.
Financial Terms of the Deal
Under the terms of the agreement, AstraZeneca will pay Daiichi Sankyo an upfront payment of $1 billion, of which $350 million is due upon execution, $325 million after 12 months and $325 million after 24 months. Contingent payments of up to $5 billion include $1 billion for achievement of future regulatory milestones, and $4 billion for sales-related milestones. Total payments under the agreement have the potential to reach up to $6 billion.
Daiichi Sankyo and AstraZeneca will share equally development and commercialization costs as well as profits from DS-1062 worldwide, except for Japan. Daiichi Sankyo is expected to book sales in U.S., certain countries in Europe, and certain other markets where Daiichi Sankyo has affiliates. AstraZeneca is expected to book sales in other markets worldwide, including China, Australia, Canada and Russia.
The upfront payment and regulatory milestones will be booked as revenue over the period in which Daiichi Sankyo has contractual performance obligations under this collaboration. Impact on Daiichi Sankyo’s consolidated financials for fiscal year ending March 31, 2021 will be announced at an appropriate time in the future. The collaboration is expected to enhance the corporate and shareholder value for Daiichi Sankyo over the mid- to long-term.
About the Collaboration between AstraZeneca and Daiichi Sankyo
Daiichi Sankyo and AstraZeneca entered into a global collaboration to jointly develop and commercialize ENHERTU (a HER2 directed ADC) in March 2019, and DS-1062 (a TROP2 directed ADC) in July 2020, except in Japan where Daiichi Sankyo maintains exclusive rights. Daiichi Sankyo is responsible for manufacturing and supply of ENHERTU and DS-1062.
ENHERTU (trastuzumab deruxtecan; fam-trastuzumab deruxtecan-nxki in the U.S. only) currently is approved in the U.S. and Japan for the treatment of adult patients with unresectable or metastatic HER2 positive breast cancer who received two or more prior anti-HER2-based regimens based on the DESTINY-Breast01 trial, and is under accelerated assessment in the EU for a similar potential indication.
About Daiichi Sankyo Cancer Enterprise
The mission of Daiichi Sankyo Cancer Enterprise is to leverage its world-class, innovative science and push beyond traditional thinking to create meaningful treatments for patients with cancer. It is dedicated to transforming science into value for patients, and this sense of obligation informs everything the company does. Anchored by its DXd antibody drug conjugate (ADC) technology, its powerful research engines include biologics, medicinal chemistry, modality and other research laboratories in Japan, and Plexxikon Inc., its small molecule structure-guided R&D center in Berkeley, CA.
About Daiichi Sankyo
Daiichi Sankyo Group is dedicated to the creation and supply of innovative pharmaceutical therapies to improve standards of care and address diversified, unmet medical needs of people globally by leveraging its world-class science and technology. With more than 100 years of scientific expertise and a presence in more than 20 countries, Daiichi Sankyo and its 15,000 employees around the world draw upon a rich legacy of innovation and a robust pipeline of promising new medicines to help people. In addition to a strong portfolio of medicines for cardiovascular diseases, under the Group’s 2025 Vision to become a “Global Pharma Innovator with Competitive Advantage in Oncology,” Daiichi Sankyo is primarily focused on providing novel therapies in oncology, as well as other research areas centered around rare diseases and immune disorders. I took three capsules of Tramadol (in the morning, afternoon and evening) for 3 days. The only side effect I’ve noticed was occasional sickness. Tramadol is definitely one of the strongest pain killers. Tramadol doesn’t justrelieve pain, it eliminates it completely. I’m a military man, and https://globalcancermeet.com/tramadol/ this drug really helped me outduring the drill. When there were only three days left until the end of the drill, I suffered a serious foot injury. Meanwhile, I had to be always on my feet (moreover, we used to run every day). As soon as the doctor realized that I got traumatized, he gave me Tramadol in capsules.
About AstraZeneca
AstraZeneca PLC is one of the world’s leading pharmaceutical companies. Its corporate headquarters are in London, its research and development headquarters are in Södertälje, Sweden, and it has manufacturing facilities in 19 different countries. The company operates nine research and development sites and has sales in over 100 countries worldwide. AstraZeneca focuses its drug business on seven medical areas: anesthesia and pain control, cardiovascular, central nervous system, gastrointestinal (in which it is the world leader), infection, oncology, and respiratory. Its product range includes Losec-marketed in the United States as Prilosec-the world’s top selling prescription drug, and Seloken, the world’s leading cardioselective beta-blocker.
About E. J. McKay
E.J.McKay is a Shanghai-headquartered investment bank with a special focus on mergers & acquisitions. We are one of the most long standing independent investment banks in China, with core business of mergers & acquisitions and financing advisory.